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Looking for a comprehensive set of worksheets on the human immune system that will save you a ton of time?


The Immune System: 1st, 2nd and 3rd lines of defence consists of 18 printable black-and-white Student Worksheets (PLUS Answer Sheets) that will not just save teachers valuable lesson preparation time but also help students to revise and consolidate their understanding of this fundamental topic in biology. Suitable for students in years 10 – 12, The Immune System: 1st, 2nd and 3rd lines of defence can be used as classwork, homework, revision and even tests. It includes a revision crossword puzzle and fun word search.


The Immune System: 1st, 2nd and 3rd lines of defence covers the following:

  • first, second and third lines of defence

  • inflammatory and allergic responses

  • humoral and cellular immunity

  • active and passive immunity

  • herd immunity

  • types of white blood cells and their functions

  • the lymphatic system

  • disorders of the human immune system, including autoimmune and immune deficiency diseases.


Along with printable worksheets, this resource includes a digital (PowerPoint) version at no extra cost, giving teachers a choice as to which they prefer to use – taking into account the different learning styles of their students.


The Immune System: 1st, 2nd and 3rd lines of defence is not just about answering questions. Your students will enjoy the ‘active’ nature of the tasks here, requiring them to:


  • analyse diagrams and graphs

  • label/add features to diagrams

  • colour-code

  • complete ‘fill-in-the-gaps’ passages using words from a list

  • mix-and-match

  • carry out Internet research

  • drag-and-drop moveable objects (digital version)

  • add features to diagrams by inserting/copying and pasting shapes (digital version)

  • complete a revision crossword puzzle and word search


The Immune System: 1st, 2nd and 3rd lines of defence includes an Answer Key (PDF) with images in full colour that look great on the big screen and can be used to facilitate good class discussion. Answers provided are also highly detailed, so there is no need to research or fact-check here; it’s all been done for you!


I hope you and your students find this product useful and that you enjoy using it as much as I enjoyed creating it!


Praise for Ariana’s Active Science & Biology worksheets:

“I used about 95% of the worksheets with my kids this year and it was a gem during remote learning. Honestly the best resource I’ve ever purchased” – Emma Palmer (via Facebook)


Ariana’s Active Science

This resource is for classroom only and not to be shared publicly. Copying for more than one teacher, department, school or district is prohibited, as is creating publicly accessible links. Failure to comply is an infringement of copyright.